I'm running Smite for Mac OSX Beta on OSX 10.11.5, using a MacBook Pro circa 2012. I've been using this Mac in bootcamp running Windows 8 to run Smite for years without any issues.

On the Mac OSX side of things, when playing the game, at various points in the game with the lowest graphic settings, we have about 0.25s freezes happening (maybe every 1 to 3 minutes), where the graphics are not updating, then it resumes rendering and you find yourself "teleported" to where you would have typically travelled to normally.

This makes fighting tough fights challenging since on occasion you can't see an enemy changing position until its too late.